Brain Ultimate TMS M-Series | FDA-Cleared TMS Device
FDA CLEARED

Brain Ultimate TMS M-Series

The Most Advanced Affordable TMS System

Experience the only TMS device that uses pure deionized water for true 24/7 operation. While others rely on transformer oil or wax composites and complex cooling systems, our proprietary design delivers continuous therapy with unmatched safety, simplicity, and no per-pulse fees.

FDA-Cleared for MDD and OCD
4 Treatment Protocols
Only Deionized Water Cooling
24/7 Continuous Operation
200+ Peer-Reviewed Publications
5,000+ Study Participants
Trusted by 75+ Clinics Clinician standing beside a patient seated in the treatment chair with the full Brain Ultimate TMS M-Series setup — stimulator, liquid-cooled coil on its positioning arm, and chair

Brain Ultimate TMS by the Numbers

24/7
Continuous Operation
4
FDA-Cleared Protocols
3 min
Fastest Treatment (iTBS)
200+
Peer-Reviewed Studies
OVERVIEW

Introduction to Transcranial Magnetic Stimulation (TMS)

Transcranial Magnetic Stimulation (TMS) is a non-invasive method of brain stimulation. It works by directing a magnetic field pulse through the skull, where it induces electrical currents in the underlying brain tissue through Faraday's law of electromagnetic induction. TMS can both depolarize and hyperpolarize cortical neurons, influencing the immediate stimulation area and connected neural structures.

Beyond the direct stimulation site, TMS influences cortical and subcortical structures connected synaptically. The neurophysiological changes induced by repetitive TMS can persist beyond the stimulation period through long-term potentiation and depression mechanisms — making TMS an effective FDA-cleared treatment for Major Depressive Disorder and Obsessive-Compulsive Disorder.

The M-100 platform is backed by dozens of published research studies, part of Brain Ultimate's comprehensive portfolio of 200+ peer-reviewed publications involving over 5,000 participants across 150+ institutions, with impact factors up to 10.7.
CAPABILITIES

M-Series Ultimate TMS Device Features

Our TMS systems adhere to international safety standards with certifications including FDA, CE, NMPA, TGA, and KFDA.

Advanced Safety Features

Comprehensive protection systems ensure patient and operator safety during every treatment session.

  • Intelligent temperature monitoring with automated safety and protection systems
  • Continuous monitoring of coolant level, temperature, and circulation
  • Enhanced patient data security with dongle authorization
  • Real-time system status indicators

Precision Positioning System

Advanced positioning technology ensures accurate and repeatable coil placement for optimal treatment outcomes.

  • 10-20 system positioning caps (S/M/L) for defined brain regions
  • Built-in coil position maps in QuickStim software
  • Flexible coil arm for precise adjustments
  • Optional Brain Ultimate Neuronavigation for tracked, image-based targeting

User-Friendly Software

QuickStim software provides comprehensive control with an intuitive touchscreen interface designed for clinical efficiency.

  • Effortless patient file creation and management
  • Built-in FDA-cleared protocols and custom protocol creation
  • Treatment records and reporting generated in the same session
  • Cloud connectivity from approved devices with QuickStim

Clinical Versatility

FDA-cleared for Major Depressive Disorder and Obsessive-Compulsive Disorder, with four distinct treatment protocols.

  • Standard MDD Protocol (19 minutes)
  • Extended MDD Protocol (37 minutes)
  • iTBS Protocol (3 minutes)
  • OCD Protocol (18 minutes)

Practice Enhancement

Maximize clinic efficiency and patient throughput with no per-pulse or per-use fees.

  • True 24/7 operation with deionized water cooling
  • 50,000,000 pulse coil lifespan
  • 1.3 kg liquid-cooled coil built for operator comfort
  • Comprehensive installation, training, and ongoing support

Integration & Compatibility

Integrates with the wider Brain Ultimate ecosystem.

  • Integrates with EB Neuro EEG within the Brain Ultimate ecosystem
  • MEP Module integration
  • Cloud-connected treatment management
  • Ethernet and USB connectivity
PROPRIETARY TECHNOLOGY

The Only TMS with Pure Deionized Water Cooling

While other systems rely on transformer oil, wax composites, and complex cooling mechanisms, our proprietary technology uses only medical-grade deionized water for unmatched safety and simplicity.

Proprietary Liquid Cooling System

Pure Deionized Water

Unlike systems built around transformer oil or wax composites, ours uses only medical-grade deionized water — no oil, no clay, no compounds — for a cleaner, safer treatment environment.

True 24/7 Operation

Continuous operation without overheating or performance degradation, with zero required downtime between treatments. Coils never need changing to cool.

Closed-Loop Safety

Sealed circulation system prevents leaks and contamination while maintaining optimal cooling efficiency with real-time temperature monitoring.

Exceptional Durability

Resistant to electrolysis, corrosion, and blockages, with minimal maintenance required.

Close-up of the Brain Ultimate TMS stimulator and deionized water cooling unit
TREATMENT COILS

One Coil, Mapped and Treated

At 1.3 kg, one of the lightest treatment coils in TMS — light enough to hold on target, session after session.

Lightweight by Design

At just 1.3 kg, the liquid-cooled coil is one of the lightest treatment coils in TMS — built for operator comfort through full treatment days.

Map and Treat With One Coil

The same coil performs motor threshold mapping and treatment. It is never swapped between the two — and never changed to cool.

On-Coil Controls

A single-pulse button and intensity adjustment sit on the coil head, so motor threshold mapping happens where your hands already are.

Two Depth Profiles

Figure-8 coils reach 2–3 cm; the Double Cone reaches 4–5 cm. Depth profile is the main difference between them.

Figure 8 Coil Flat
Figure-8 — 2–3 cm depth
Liquid Double Cone Coil
Double Cone — 4–5 cm depth
Between the two depth profiles, the coil set covers the cortical target depths of every FDA-cleared protocol on this system — the figure-8 drives the MDD and iTBS protocols, and the Double Cone is used with the FDA-cleared OCD protocol.
TECHNICAL DETAILS

Comprehensive Specifications

FDA Clearance
K230735 (MDD) · K243459 (OCD) · K243460 (iTBS)
Cleared Indications
Major Depressive Disorder · Obsessive-Compulsive Disorder
Protocols
4 FDA-Cleared
Cooling System
Proprietary Deionized Water
Operation Mode
24/7 Continuous
Software
QuickStim 3.3.9
Frequency Range
0.1 – 100 Hz
Intensity Range
0 – 200% MT (software), up to 100% system output
Pulse Width
Biphasic (~100 µs)
Coil Type
Figure-8 Liquid Cooled
Coil Weight
1.3 kg
Depth Profiles
Figure-8: 2–3 cm · Double Cone: 4–5 cm
Coil Lifespan
50,000,000 pulses
Max Pulses/Session
Unlimited (24/7 capable)
Thermal Protection
Intelligent temperature monitoring with automated warning and shutdown
Monitoring
Real-time temperature, coolant, status
Data Security
Dongle authorization + encrypted storage
Emergency Stop
Hardware and software
EMC Compliance
IEC 60601-1-2
Native Power
230VAC / 50Hz
US Configuration
Integrated step-down transformer (110V → 230V)
Max Input Power
3,500W
Minimum Site Capacity
5 kVA
Certifications
FDA, CE, NMPA, TGA, KFDA
Display
Touch Screen
Connectivity
Ethernet, USB
Included Chair
Ergonomic Patient Chair
INTUITIVE CONTROL

QuickStim Software Platform

Comprehensive software designed for clinical efficiency with cloud connectivity from approved devices.

QuickStim patient management interface
Close-up of the QuickStim interface showing an option being selected
QuickStim protocol creation screen
QuickStim database of saved protocols

Streamlined Clinical Workflow

QuickStim software simplifies every aspect of TMS treatment delivery, from patient intake to treatment completion and reporting.

  • Effortless Patient ManagementQuick patient file creation, comprehensive history tracking, and secure data storage with dongle authorization.
  • Built-in FDA-Cleared ProtocolsPre-loaded with all 4 FDA-cleared protocols plus custom protocol creation.
  • Cloud ConnectivityAccess patient data across devices with Brain Ultimate Cloud integration — from approved devices where QuickStim is installed.
  • Comprehensive ReportingGenerate treatment summaries, progress reports, and session documentation for clinical records.

Experience Our Technology Firsthand

Join the 75+ clinics nationwide that trust Brain Ultimate for reliable, affordable, and advanced TMS therapy — backed by 200+ peer-reviewed studies and no per-pulse fees.

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